Wales head coach Steve Tandy made six changes to the starting XV which lost 35-21 to Argentina last weekend for the Nations Championship Test with world champions South Africa in Durban on Saturday.
He chose a new centre partnership with Max Llewellyn and Ben Thomas replacing Eddie James and Joe Hawkins.
Louis Rees-Zammit, who began the first round victory over Fiji, returns to the right wing in place of Ellis Mee.
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